Abstract
The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline to get 2-amino-6-fluoro-7-chloro (1,3) benzothiazole (I), this was treated with anilino-s-methyl ethylene cyanoacetamide in the presence of ethanol to get desired molecules. The synthesized targeted molecules are characterized, docked and screened for their invitro antidiabetic properties.
 Keywords: Fluorobenzothiazole, Docking, antidiabetic
Highlights
IntroductionFluorobenzothiazole[1] comprising sulfonamide pyrazole derivatives have been synthesized and evaluated for their various activities
Fluorobenzothiazole[1] comprising sulfonamide pyrazole derivatives have been synthesized and evaluated for their various activities.The sulfonamide[2,3,4,5] drugs were the first effective chemotherapeutic agents to be employed systemically for the prevention and cure of bacterial infection in human beings
The introduction of trimethaprim and sulphamethoxazole has resulted in increased use of sulfonamide for the treatment of specific microbial infection
Summary
Fluorobenzothiazole[1] comprising sulfonamide pyrazole derivatives have been synthesized and evaluated for their various activities. The sulfonamide[2,3,4,5] drugs were the first effective chemotherapeutic agents to be employed systemically for the prevention and cure of bacterial infection in human beings. The introduction of trimethaprim and sulphamethoxazole has resulted in increased use of sulfonamide for the treatment of specific microbial infection. Benzothiazoles with sulphonyl group and pyrazole etc were reported to posses various pharmacological activity of clinical importance. The chemistry and pharmacology of pyrazole[6,7,8,9,10] have been of great interest because pyrazole derivatives possess various biological activities. In present work we have prepared sulphonamido-pyrazole analogs incorporate with substituted benzothiazole
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