Abstract
Objective: This study aimed synthesis of fused pyridine due to the importance of these heterocycles as antimicrobial and anticancer. Method: Some novel substitutedpyrido[3,2-c]pyran-6-one,pyrido[2,3-c]isoxazole,pyrazolo[4,3-c] pyridine, pyrido[4,3-c]pyrimidine, pyrido[3,2-c]pyrimidine[2,3-b]triazine-2-thione and pyrido[3,2-c]pyrano[2,4-d] pyrimidine-2-thione derivatives have been reported to possess various pharmacological activities like antimicrobial and antitumor. Results: A novel series of azoles and azines were designed and prepared via reaction of 3-(arylidene)-1-methy-4-piperidonewith some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Conclusion: It could be concluded that the tested compounds 14a,e, 13a, 11b and 17d1 have highest antibacterial activity. Compounds 11b, 13a, 14c,e,g, 16e, 17d1 have antifungal activity than antibiotic standard (Nystatin) used. Compound 13a and 25a have shown good anticancer agent. ifungal activity than antibiotic standard (Nystatin) used. Compound 13a and 25a have shown good anticancer agent.
Highlights
Designing of novel class of bioactive heterocycles and develop efficient methods for their synthesis with predefined functionalities is a challenging task in modern organic chemistry
Encouraged with the above survey, the present study aimed to develop and synthesize novel compounds bearing pyranopyridine, pyridopyrimidine and pyrazolopyridine rings and test their biological activity as antimicrobial, antifungal and anticancer
Part 2-Biological results Preliminary screening for the antimicrobial activity of the synthesized compounds using the agar diffusion technique against Bacillus cereus, Staphylococcus aureus and Candida albicans showed that a concentration of 200 g/ml dissolved in dimethylformamide (DMF)
Summary
Designing of novel class of bioactive heterocycles and develop efficient methods for their synthesis with predefined functionalities is a challenging task in modern organic chemistry. Pyrimidine and pyrazole are interesting classes of compounds both chemically and biologically.[1,2,3,4] For example, pyrazolopyridines exhibited various biological activities such as antimicrobial, antiinflammatory and antitumor.[4,5,6,7,8,9,10,11,12]. Pyrano[2,3-B]pyridine and pyridopyrimidines which possess antimicrobial and antioxidant 13,20. Encouraged with the above survey, the present study aimed to develop and synthesize novel compounds bearing pyranopyridine, pyridopyrimidine and pyrazolopyridine rings and test their biological activity as antimicrobial, antifungal and anticancer
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