Abstract
Small heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields. A convenient and high-yielding synthetic approach for a range of organic molecules is presented. The nuclease-like activities of compounds were studied with the aid of E. coli AB1157 DNA and agarose gel electrophoresis. The antioxidant evaluation of the compounds was carried out with different antioxidant techniques, such as ABTS and NO scavenging efficiency. The antibacterial behavior was evaluated against various bacterial strains, both Gram-positive and -negative, and the minimum inhibitory concentration (MIC) values of these compounds were determined. The antiproliferative activities and IC50 values of the synthesized organic molecules compounds against HEPG-2, MCF-7, and HCT-116 cell lines were evaluated.
Highlights
Hydrazonoyl halides are pivotal in chemical synthesis due to the fact that these compounds are synthetic precursors that generate a large number of alicyclic and organic molecules
We report here a rapid and simple method to synthesize thiazoles in excellent yield and short reaction time
The first step involved the preparation of thiosemicarbazones 2a, 2b, and 3 by reaction of aldehyde with thiosemicarbazide
Summary
Hydrazonoyl halides are pivotal in chemical synthesis due to the fact that these compounds are synthetic precursors that generate a large number of alicyclic and organic molecules. Thiazole derivatives are present in numerous pharmaceutically active compounds and play a significant role in agricultural industry. These have been reported to display antimicrobial [6,7], anti-rheumatoid [8], anti-hypertensive [9], anti-human immunodeficiency virus (HIV) [10], anticancer [11], antifever [12], anticonvulsant [13], herbicidal, insecticidal, schistosomicidal, and anthelmintic [14] activities. Vitamin B1 contains a thiazole ring in its structure, and this vitamin plays an essential role as coenzyme in the decarboxylation process of carbohydrate metabolism [15]. A large number of thiazole-containing pharmaceutical compounds are present in several drug molecules, such as Tiazofurin (antineoplastic mediators), Bleomycin [16], Ritonavir (anti-HIV medication) [17], Fanetizole and Meloxicam (arthritis mediators) [18], Nizatidine (antiulcer mediator) [19], Imidacloprid (insecticide), and sulfathiazole as an antibiotic [20]
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