Abstract
We describe here the synthesis and biological evaluation of a series of benzo[ b]naphthyridones, a new family of tricyclic antibacterial compounds that have a Gram-positive spectrum of activity. RP60556A, one of the most potent of these compounds, is bactericidal against multiresistant cocci, especially multiresistant Staphylococcus aureus strains. Its physico-chemical and biological properties make it particularly suitable for topical antibacterial use.
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