Abstract
A new bunch of aryl sulfonyl linked isoxazol-(pyridin-4-yl)pyrazolo [1,5-a]pyrimidine compounds ( 11a–j ) have been designed, developed and their structure were characterized by analytical techniques. Further, compounds were tested for their cytotoxicity activities towards human cancer cell lines like SiHa (Cervix cancer), A549 (Lung cancer), MCF-7 (Breast cancer) and Colo-205 (Colon cancer) using MTT assay and compared with standard drug, etoposide. Among all, compounds 11a, 11b, 11c, 11d and 11e demonstrated good cytotoxicity effects as standard drug. Specifically, two compounds ( 11a and 11e ) displayed more potent activity.
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