Abstract
In the present investigation, two new series, 1-(4-benzylphenyl)-3-(5-substituted-1,3,4-oxadiazol-2-yl)-1-propanone and 1-(4-ethylphenyl)-3-(5-substituted-1,3,4-oxadiazol-2-yl)-1-propanone from β-(4-benzylbenzoyl)propionic acid and β-(4-ethylbenzoyl)propionic acid, respectively, were synthesized and tested for antiinflammatory, analgesic, lipid peroxidation, ulcerogenic and antibacterial actions. A fair number of compounds were found to have good antiinflammatory activity in carrageenan-induced rat paw edema test, while a few compounds showed significant antibacterial activity. The newly synthesized compounds showed very low ulcerogenic action.
Highlights
Ropinirole hydrochloride exhibits its maximum absorption at 250 nm and obeyed Beer’s law in the range of 5-35 μg/ml
The results of analysis and recovery studies are presented in the Table 1
The percentage recovery value 99%-101% indicates that there is no interference from the excipients present in the formulation
Summary
SD is standard deviation, SE is standard error and COV is coefficient of variation. 100.61 μg/cm2/0.001-absorbance units. SD is standard deviation, SE is standard error and COV is coefficient of variation. Linear regression of absorbance Vs concentration yielded equation y=0.0293x+0.00357 with a correlation coefficient of 0.9998. Relative standard deviation of 0.00608 was observed for analysis of three replicate samples, indicating precision and reproducibility. Ropinirole hydrochloride exhibits its maximum absorption at 250 nm and obeyed Beer’s law in the range of 5-35 μg/ml. The results of analysis and recovery studies are presented in the Table 1. The percentage recovery value 99%-101% indicates that there is no interference from the excipients present in the formulation. The developed method was found to be sensitive, accurate, precise and reproducible and can be used for the routine quality control analysis of ropinirole hydrochloride in bulk drugs and formulations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
