Abstract
A new [ 18F] labeled amino acid anti-1-amino-2-[ 18F]fluoro-cyclobutyl-1-carboxylic acid 9 ( anti-2-[ 18F]FACBC) was synthesized in 30% decay-corrected yield with high radiochemical purity over 99%. The cyclic sulfamidate precursor was very stable and highly reactive towards nucleophilic radiofluorination. Cell uptake assays with rat 9L gliosarcoma cells showed that [ 18F] 9 was transported into tumor cells via multiple amino acid transport systems, including L and A systems. Biodistribution study in rats with intracranial 9L gliosarcoma tumors demonstrated that [ 18F] 9 had a rapid and prolonged accumulation in tumors with 26:1 tumor to brain ratio at 120 min post-injection. In this model, [ 18F] 9 is a potential PET tracer for brain tumor imaging.
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