Synthesis and biological evaluation of 2-aryl-3-isoxazolinyl-indole derivatives as anti-inflammatory agents

Abstract

The reaction of 2-aryl-1H-indole-3-carboxaldehydes with substituted acetophenones in ethylene glycol and piperidine as a base gives the indole chalcones(4a-4f).Which on subsequent treatment with hydroxylamine hydrochloride in presence of base resulted in the cyclization of α, β-unsaturated ketone into the title compound (5a-5f) in 60-70% yield after column purification. The purity of the compounds was checked by TLC in ethylacetate: hexane (3:7). The structures of the all the compounds were established by 1 H - NMR, IR, LCMS and elemental analysis. The synthesized compounds (5a-5f) were evaluated for their anti-inflammatory activity.