Abstract
Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Among them, 11 derivatives were found to inhibit the enzyme in the submicromolar range; the best compound revealed its inhibitory activity with an IC 50 in the same range (0.06 μM) than the reference compound, donepezil (IC 50 = 0.02 μM).
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