Abstract
3β-Amino compounds with 17β-(3-furyl) and (4-pyridazinyl) ring systems were prepared from digitoxigenin lb and found to have similar cardiotonic properties to the analogous 3β-hydroxy compounds when tested in the isolated guinea-pig atrial preparation. Derivatives with 3α-acetoxy functions were found to have higher than expected activities. Particularly potent was the pyridazine N 1-oxide 19. All isocardenolides and the unsaturated anhydride 18 were devoid of activity.
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