Abstract
Five flavonoids 5,7,3',4'-tetramethoxyflavonol (1), 5,7,3'-tribenzyloxy-4'-methoxy flavonol (2), 5,7,4'-trimethoxyflavonol (3), acacetin (4) and 5,7-dihydroxy-4'-benzyloxyflavone (5) were synthesized from diosmetin or rhoifolin by O-methylation, dehydrogenation, glycoside hydrolysis, O-benzylation and dimethyldioxirane (DMDO) oxidation. Based on “Click chemistry”, ten novel flavonoids galactoconjugates 11~20 were synthesized in good yield using copper-mediated 1,3-dipolar cycloaddition reactions of acetylgalactose azides and alkynyl-substituted flavonoids 6~10. Their biological activities against five human cancer cell lines were evaluated by the standard MTT method. The results showed that 11, 13 and 20 exhibited moderate cytotoxicity against HL-60, SMMC-7721, MCF-7, SW480 and A-549 cancer cell lines.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
