Abstract

The title congeners were synthesized by employing our efficient synthetic route previously explored for preparing enantiomeric pairs of thiolactomycin and its 3-demethyl derivative. While all the synthesized congeners lacked in vitro antibacterial activity, some of the congeners bearing an ( E)-cyclohept-2-enylidenemethyl or an ( E)-cyclooct-2-enylidenemethyl group were found to exhibit more potent type I FAS inhibitory activity than ( S)-3-demethylthiolactomycin having an unnatural configuration.

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