Abstract
Two analogs of porcine motilin altered at position 8, [L-Ala8]-motilin and [D-Ala8]-motilin, were prepared by the conventional solution method via the corresponding sulfoxides (Met13) and evaluated in vitro for the ability to contract the duodenal muscle of rabbit. The D-Ala analog exhibited a higher potency than synthetic motilin, whereas substitution of glycine at position 8 with L-alanine decreased the biological activity to approximately 30% relative to the synthetic motilin.
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