Abstract
A series of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrroline-2-ones was synthesized via the reactions of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and 2-(4-morpholino)-1-ethylamine or 3-(4-morpholino)-1-propylamine. All compounds possess weak antibacterial properties. The antiamnesic, analgesic, and antiphlogistic activity and acute toxicity of several compounds were studied. It was established that one compound produced a significant antiamnesic effect and two compounds exhibited pronounced analgesic activity.
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