Synthesis and biological activity evaluation of some new mixed azines appended tetrahydro-1,2,4-triazines

Abstract

A series of 6-acetyl-2,4-diaryl-2,3,4,5-tetrahydro-1,2,4-triazines (2a–2f) was synthesized by double Mannich reaction of the hydrazone 1a or 1b with formaldehyde and the appropriate amine. A similar reaction of 1a with the appropriate diamine afforded the bis(tetrahydro-triazines) 3a–b, and 4a–b. Whereas, the 6-cinnamoyl derivatives 5a-c were obtained by the reaction of 2a with the appropriate aldehyde. The hydrazone 7, derived from 2a, was treated with the appropriate aldehyde or ketone to afford the mixed azines 8–12 and 13–16. The biological activity, antibacterial, antifungal and antioxidants of the most newly synthesized compounds of these derivatives were screened. Compounds 2b, 3a and 7 revealed the best results against all screened biological activity