Synthesis and biological activities of O‐(E)‐(arylmethyl) 1‐[1‐(arylmethyl)‐5‐methyl‐1H‐1,2,3‐triazol‐4‐yl] ethanone oxime ethers

Abstract

Abstract magnified image A series of novel O‐(E)‐(arylmethyl) 1‐[1‐(arylmethyl)‐5‐methyl‐1H‐1,2,3‐triazol‐4‐yl] ethanone oxime ethers were synthesized by the O‐alkylation of 1‐[1‐(arylmethyl)‐5‐methyl‐1H‐1,2,3‐triazol‐4‐yl] ethanone oximes with various arylmethyl chlorides in the basic condition. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The preliminary bioassay indicated that some of the target compounds (4a, 4b, 4c, 4d, 4e, 4f) displayed good insecticidal and moderate fungicidal activity. For example, compounds 4c and 4g showed 100% and 90.6% death rates against aphides at the concentration of 250 mg/L, respectively, and compounds 4f and 4g displayed 67% and 78.4% inhibitory rates against Rhizoctonia solani at the dosage of 100 mg/L, respectively. J. Heterocyclic Chem., (2009).