Abstract
Abstract (−)-Indolactam-V ( 1 ) exists as two stable conformers, the twist and the sofa form, in solution at room temperature. 3-Aza-Cope rearrangement of (−)- N 13 -desmethyl- N 13 -allylindolactam-V ( 5 ) gave new conformationally restricted analogues ( 2a and 3 ) along with a normal rearrangement product ( 7 ). Both 2a and 3 , whose fixed conformation was the twist form, showed significant biological activities related to tumor promotion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
