Abstract
Abstract Fast, simple, and environmentally friendly gold nanoparticles (Au-NPs) capped and stabilized with black cumin (Bunium persicum) seed alcohol extract are reported. The aqueous gold ions (Au3+) were treated with B. persicum (BP) seed extract, which resulted in a rapid color change to red, indicating the synthesis of Au-NPs. UV-Vis spectroscopy, FTIR, SEM, energy dispersive X-ray (EDX), and X-ray diffraction (XRD) techniques were used to further characterize the Au-NPs. Its stability was assessed against various pH levels and sodium chloride levels (NaCl), different salts of same concentration as well as at a range of temperature (30–100°C). The UV-Vis spectrum in the Au-NPs produced a 540 nm plasmon surface resonance, and a 25–50 nm range of particulates was shown in the SEM analysis. In addition, the FTIR spectra confirmed the inclusion in the capping and decrease of Au-NPs of amines, amide groups, and alcohols. The EDX analysis confirmed the presence of element Au. Furthermore, Au-NPs were tested for enzyme inhibition and antibacterial and antifungal activities and showed remarkable response. These findings have concluded that BP seed extract is an effective bio-reductant of gold nanoparticle synthesis, which can be further applied in different biomedical and pharmaceutical industries.
Highlights
Gold and silver nanoparticles in particular attracted significant attention in sensing, imaging, and biomedical devices [1]
Natural medicinal herbs are widely utilized across the world to treat chronic illnesses, ranging from acute to severe
The main indicator that this metal nanoparticle is biosynthesized successfully is the change of solution color
Summary
Biosynthesis of black cumin seeds (Bunium persicum) 441 and diagnosis of cancer through MRI [10] are some examples of nanoparticle application in medical fields. The green synthesis of nanoparticles through eco-friendly synthesis methods is gaining attention among researcher community because they do not require high pressure, temperature, and toxic chemicals. The microorganisms that are used for the synthesis of metal nanoparticles are bacteria [22] and fungi [23], and plant extracts [24] are used for the synthesis of green nanoparticles. These biologic systems have the ability to synthesize nanoparticles in safe, easy, and economical way. The use of plant-based nanoparticles for the removal of toxic materials from waste water has the benefit of being of eco-friendly nature, easy to be synthesized, and readily accessible substrates. 2 Materials and methods tetrachloroaurate trihydrate (HAuCl4‧3H2O), methanol, and sodium chloride were obtained from Merck, Germany
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