Abstract
以3．甲基-2-氰基吡啶为原料，经水解、酯化、硝化、甲氧基取代、溴代反应制得中间体3-溴甲基-5-甲氧基吡啶-2-甲酸甲酯（7），然后中间体与不同的有机胺经环合反应得到-系列新的沙利度胺衍生物3-甲氧基-6-取代-5，6-二氢吡咯[3,4-b]吡啶-7-酮1a-11．其结构经。HNMR，13CNMR及HRMS确证．采用MTT（噻唑蓝）法测试了目标化合物抑制HCT-116，MG-63，MCF-7，HUVEC及HMVEC细胞的活性，结果表明，几乎所有化合物对人体正常细胞无明显抑制作用，化合物1h-11只对MG-63细胞株有明显的抑制活性，化合物1c-1g对这三种肿瘤细胞都有较强的抑制活性，其中化合物1d和1e活性最强．
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