Abstract
Go indigo: Carbohydrate derivatives of indigoid bis-indoles are effective inhibitors of several kinases, such as CDKs and GSK-3β. Recent studies have shown that thia analogues of glycosylated indirubins are good candidates for the treatment of malignant melanoma. Herein we review the progress made in synthesis and biological screening of various carbohydrate derivatives of indigo, its isomers, and their heteroanalogues with special focus on synthetic issues.
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