Abstract
The present study was designed to synthesize and evaluate the analgesic of hybrid molecules (mutual prodrugs) of tramadol with ibuprofen, diclofenac sodium, and mefenamic acid. Analgesic activity was assessed on albino rats by using the tail-flick method. Synthesized mutual prodrugs were characterized by carbon, hydrogen, and Nitrogen analysis, infra-red spectroscopy and Nuclear magnetic resonance spectroscopy. The kinetics of chemical hydrolysis of the synthesized mutual prodrugs of tramadol was studied at 370C in aqueous buffer solutions of pH 1.2 and pH 7.4. For evaluating the analgesic activity, synthesized mutual prodrugs were administered at 50 mg/kg to albino rats by intraperitoneal route. The results showed that all hybrid molecules were effective as analgesics, among them Ibuprofen-containing mutual prodrug showed higher analgesic activity than others. Molecular docking results also supports the finding of pharmacological evaluation.
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