Abstract
Analogues of the tumor-associated T-antigen (βGal1,3αGalNAc) containing 4,6-epidithio and 4,6-thietan modifications were synthesized from the α-allyl glycoside of βGalα1,3G1cNAc via suitable thiocyanate derivatives. Binding to three leguminous lectins as model systems was investigated in an enzyme-linked lectin assay (ELLA) and IC 50 values comparable to the corresponding natural disaccharides T-antigen, lactose and N-acetyllactosamine were found.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
