Synthesis and Assessment of Sub-acute Toxicity of Novel Rosin Esters of Polyethylene Glycol 200 in Swiss Albino Mice

Abstract

The objective of present investigation was to synthesize and assess sub-acute toxicity of novel rosin esters using Swiss Albino mice. Assessment of the safety and toxicity of rosin esters is very important step before its use in pharmaceuticals. The solutions of rosin esters were prepared in corn oil to perform acute (28d) oral toxicity study in Swiss Albino mice as animal model of both sexes. The oral administration of rosin esters at the dose of 25 mg/kg of body weight and constant volume was administered to the mice. One group of mice was kept as a control group. Toxicity of the rosin esters was assessed by using various tests like behavioral changes, clinical signs, mortality and morbidity, biochemical tests, haematological tests, relative organ weights and histopathology tests. The body weights and food-water consumption by mice were recorded on weekly basis. The study results revealed that, there were no signs and incidences of toxicity or mortality in mice during the study period. No significant difference between treated (rosin ester administered) and control group of mice were recorded in the observations of different tests, body weights and food-water consumption. The histopathological examination of organs from the mice treated with rosin esters for 28d does not show any signs of toxic effects when compared with the control group. Therefore, the present investigation confirmed the non-toxic nature of novel rosin ester at 25mg/kg daily dose of body weight after oral administration in both the sexes.