Abstract
BackgroundMagnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier.MethodsMagnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively.ResultsThe results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect.ConclusionThe Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.
Highlights
Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties
In‐situ synthesis of Fe3O4@Layered double hydroxides (LDHs) multicore@shell nanostructure The experimental procedure for the preparation of layered double hydroxide nanoflake on Fe3O4 was similar to that described in the literature
The Fe3O4@LDH multicore-shell nanostructure was synthesized in two steps: firstly, magnetite nanoparticles were synthesized by solvothermal and Ostwald ripening method, and layered double hydroxide nanoflakes were prepared on the magnetic nanoparticles by in-situ coprecipitation method and used as the new nanocarrier
Summary
Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. The primary constituents of LDHs are the charged layers that provide diverse chemical compounds with versatile usability, for example, biocompatibility, adsorption, intercalation, and ion exchange [9,10,11]. These are the bases of LDHs diverse technology applications in a variety of fields including medicine, polymer industries, electrochemistry, food, catalysis, drug delivery separation, and more. Even so, layered double hydroxide nanoparticles are aggregated in phosphate buffered saline solution that reduces the number of proper sized nanoparticles available for internalization and, as a result, affect the delivery efficiency [13]. LDHs containing magnesium and aluminum have already been used as an antacid and antipepsin agent; LDH is quite biocompatible
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