Abstract
A new, crystalline 5′-thiol modifier phosphoramidite monomer ( 3), suitable for DNA synthesis, has been prepared. This monomer has been built into an oligonucleotide using the standard protocol. After cleavage, purification and removal of the trityl group with Ag +, a free 5′-thiol terminal oligonucleotide ( 15) has been obtained which was subsequently coupled to a cysteine derivative via a disulfide bridge to afford conjugate 16.
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