Abstract
A new fluorous proline-derived ligand has been synthesized and applied to the copper-catalyzed Henry reaction.The reaction conditions were optimized in terms of ligand,Cu source,solvent and base taking the reaction of 4-nitrobenzaldehyde and nitromethane as a model reaction.The optimized conditions are:using fluorous proline imide as ligand,copper acetate as copper source,methanol as solvent and triethylamine as base and the reaction was carried out at room temperature.A wide range of substrates were investigated under the optimized conditions and the yields of the target products varied from 53% to 98%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
