Abstract
Several 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes ( 7– 21) as conformationally rigid analogues of fluoxetine were synthesized and evaluated for their anorexigenic and antidepressant activities. For SAR studies the related acyclic analogues ( 22– 27) were also prepared. Out of the 21 synthesized compounds, 10 compounds ( 9, 10, 11, 15, 16, 18, 21, 22, 23 and 27) exhibited significant anorexigenic activity (at 75 μmol/kg). Interestingly, all the compounds ( 7– 20, 22– 26) were devoid of antidepressant effect, except for compounds 21 and 27 in which the antidepressant activity was retained. Compound 16 emerged as the most active compound of the series with better anorexigenic activity (97.92%) compared to fluoxetine (76.25%) and even with a clinically used drug sibutramine, thus providing a new structural lead for appetite suppressants.
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