Abstract
This research reported the design and synthesis of some influential new pyrrolone derivatives bearing a pyrazole scaffold with the evaluation of their antiviral activity against Newcastle disease virus (NDV) in specific pathogen free (SPF) chicken embryos and immune boosting properties of these substances in SPF chicks. The building block synthon was the pyrazolyl acid hydrazide, derived from 2(3H)-furanone, which was reacted with some carbonyl compounds, e.g., salicylaldehyde, furfural, 1,3-diphenylpyrazole-4-carbaldehyde, 2-chloroquinoline-3-carbaldehyde, chromone-3-carbaldehyde, and 3-acetylcoumarin. The results revealed that pyrazole derivative 6, quinoline derivatives 7 and 8 exhibited 100% protection against NDV while the hydroxyphenyl derivative 3 showed 95% protection. In turn, chromone derivative 10 and coumarin derivative 11 exhibited 90% protection. The structures of all products were established on the basis of their elemental analyses and spectroscopic techniques.
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