Abstract
Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P1-9) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A1-3) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was evaluated using reduction in total acidity, free acidity and ulcer index as parameters. Compounds P3, P6, P7 and P9(100 mg/kg) showed significant (P< 0.001) antiulcer action compared to control and omeprazole (40 mg/kg).
Highlights
(A1-3) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl3-methyl-5-pyrazolone
280805 is the prototype of a reversible proton pump inhibitor, which is effective in ulcer healing yet avoid prolonged achlorhydria
Keeping in view this structural flexibility and capitalizing on the basic structural feature, we thought to explore several benzimidazole, benzotriazole and benzothiazole derivatives to find some alternatives to the present irreversible proton pump inhibitors
Summary
(A1-3) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl3-methyl-5-pyrazolone. 280805 is the prototype of a reversible proton pump inhibitor, which is effective in ulcer healing yet avoid prolonged achlorhydria. Keeping in view this structural flexibility and capitalizing on the basic structural feature, we thought to explore several benzimidazole, benzotriazole and benzothiazole derivatives to find some alternatives to the present irreversible proton pump inhibitors. Different 2-(1’-iminothioimido substituted)-1’-substituted phenyl benzoic acids (P1-9) D- 6) spectra of title compounds were recorded on a Bruker DRX-300 NMR spectrophotometer
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.