Abstract
Abstract To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one, mono-Schiff bases 6a–6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a–4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized, and their in vitro antitumor activity against CHO, HL60, L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.
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Schedule a callMore From: Chinese chemical letters = Zhongguo hua xue kuai bao
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