Abstract
3-Thio-4-phenyl-5-[2-(4-)benzyloxyphenyl]-1,2,4-triazoles were prepared by cyclization of the corresponding thiosemicarbazides in alkaline medium. The 2-N-substituted derivatives of the aforementioned triazoles were obtained via aminomethylation, cyanethylation, and alkylation of α-epoxides. 3-S-Substituted 1,2,4-triazoles were synthesized by alkylation with various aliphatic and aromatic halides. Acylhydrazides were prepared via reaction of 2-(4-)benzyloxybenzoic acid hydrazides with dicarboxylic acid anhydrides. The antitumor activity of the synthesized compounds was studied.
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