Abstract
Using 2-thiophenecarbonyl chloride and 2-furoyl chloride to modify the structure of the natural product resveratrol, we synthesized five novel resveratrol derivatives. The target compounds were evaluated for their antitumor activities against cervical cancer HeLa cells by the MTT method. The results indicated that the compound 3a displayed the best antitumor activities, which is higher than the value of resveratrol, and its inhibition ratio was 95.1% against HeLa cells at the concentration of 75 μmol/L.
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