Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates

Abstract

New hetero(μ 3-oxo)trinuclear iron(III) furoates with the general formulas [Fe 2MO(α-Fur) 6(L)(H 2O) 2], where L = THF ( 1– 3), DMF ( 4– 5), M = Mn 2+ ( 1, 4), Co 2+ ( 2, 5), Ni 2+ ( 3, 6) and [Fe 2MO(α-Fur) 6(3Cl-Py) 3], where M = Mn 2+ ( 7), Co 2+ ( 8), Ni 2+ ( 9); have been synthesised and investigated by Mössbauer and IR spectroscopies. The X-ray crystal structure has been determined for the 4 and 8 complexes, indicating that they are related to the monoclinic crystal system (P2 1/n) and have a structure typical of μ 3-O-bridged trinuclear iron (III) compounds. The 57Fe Mössbauer spectra of microcrystalline samples of the compounds indicate the presence of high-spin iron (III) ( S = 5/2) with a near symmetrical environments. The iron(III)–cobalt(II) containing compounds 2, 5 and 8 displayed MIC values between 0.83 ÷ 4.00 μg/mL.