Abstract
Conjugate addition of diamines to glycosyl olefinic esters 1a and 1b followed by reduction of resulting bis-glycosyl β-amino esters ( 2–7 and 14–19) with lithium aluminium hydride led to the respective glycosyl amino alcohols ( 8–13 and 20–25) in moderate to good yields. All the compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H 37Ra and H 37Rv. Few of the compounds exhibited antitubercular activity with MIC as low as 6.25–3.12 μg/mL in virulent and avirulent strains. Compound 13 was found to be active against MDR strain and showed mild protection in mice.
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