Abstract
In this work we reported the synthesis and the trypanocidal profile of new 1,3,4-thiadiazole-2-arylhydrazone derivatives of nitroimidazole series ( 4) or phenyl series ( 5), designed by exploring the molecular hybridization approach between megazol ( 2) and guanyl hydrazone derivative ( 3). The evaluation of the activity against bloodstream trypomastigote forms of Trypanosoma cruzi forms lead us to identify a new potent trypamomicide prototype, that is, brazilizone A ( 4k), which present an IC 50/24 h = 5.3 μM.
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