Abstract
Pyrrolo(1,2-a)imidazole and pyrrolo(2,1-b)thia- zole derivatives were synthesized in a one-pot procedure by (3 ? 2) cycloaddition reactions of the corresponding imidazolium ylides and thiazolium ylides with an alkene followed by oxidative aromatization of the primary cycloadducts under the action of the mild oxidant tetra- kispyridinecobalt(II) dichromate. Antiproliferative activity of 14 new bicyclic N-fused heterocycles against the human hepatocellular liver carcinoma (Hep-G2) cell line were examined by the MTT method. Some of the compounds showed favorable antiproliferative activity, especially compound 3i displayed potent antiproliferative activities with an IC50 value of 0.36 lg/cm 3 .
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