Abstract
Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (>0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs; IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations.
Highlights
In the race to synthesize new pharmceutical drugs, ionic liquids (ILs) have attracted a great deal of attention amongst in the scientific community due to their variety of potential pharmaceutical applications
The data obtained by the metabolic cell death (MTT) assay show that ILs 1, 2, 3 and 4 had inhibitory effects on the growth of T98G
These ILs were more efficacious on T98G cancer cells and less toxic to Human Embryonic Kidney (HEK)
Summary
In the race to synthesize new pharmceutical drugs, ionic liquids (ILs) have attracted a great deal of attention amongst in the scientific community due to their variety of potential pharmaceutical applications. Enzymes suspended in the ILs could be reused three times, with less than 10% loss of activity per cycle without influencing enantioselectivity [22] Based on these interesting properties, ILs appear ready to provide a new research outlook in the field of medicinal chemistry. Cytotoxicity of the synthesized ILs on normal cells were assessed using the HEK cell line, which resembles developing neuron and neuronal stem cells and is mentioned as a good model for neuroscience studies [25] Based on this background, we have used HEK normal cells as a model for brain normal cells in this study
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