Synthesis and antioxidant activities of some novel fluorinated spiro[oxindole-thiazolidine] fused with sulfur and phosphorus heterocycles

Abstract

Facile routes were achieved for the synthesis of novel fluorinated spiro[oxindole-thiazolidinone] fused with some sulfur and phosphorus heterocycles starting from 5-fluoro-3′-(4-fluorophenyl)-4′H-spiro[indole-3,2′-thiazolidine]-2,4′(1H)-dione (1) via its reaction with trifluoroacetamide, 2-chloro-6-fluorobenzaldehyde and hydrazine hydrate followed by treatment with some suitable sulfur and phosphorus reagents. The antioxidant activities of the synthesized compounds were also evaluated.