Abstract
In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series ( 5) and benzoic acid series ( 6), designed by exploring the molecular hybridization approach between isoniazid ( 1) and trans-cinnamic acid derivative ( 3). The minimum inhibitory concentration (MIC) of the compounds 5a– d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
