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Abstract
In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series ( 5) and benzoic acid series ( 6), designed by exploring the molecular hybridization approach between isoniazid ( 1) and trans-cinnamic acid derivative ( 3). The minimum inhibitory concentration (MIC) of the compounds 5a– d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.
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