Abstract
A series of 8 H-7-(substituted aryl)-3-(4-methylthiobenzyl)-1,3,4-thiadiazino[2,3- c]-1,2,4-triazin-4-ones ( 4 ) were synthesized in good yield by condensing 4-amino-6-(4-methylthiobenzyl)-3-mercapto-1,2,4-triazin-5(4 H)-one 1 with various substituted phenacyl bromides (2) in presence of anhydrous sodium acetate, followed by the cyclization of the intermediate triazinone derivatives (3) in presence of concentrated sulphuric acid. The structures of the newly synthesized compounds were formulated on the basis of elemental analysis, IR, 1H NMR and mass spectral studies. The newly synthesized compounds were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Phosphorus, Sulfur, and Silicon and the Related Elements
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
