Abstract
Efficient, environmentally and economically sustainable, and nontoxic antibacterial products are of global relevance in the fight against microorganism contamination. In this work, an easy and straightforward method for the synthesis of bis‐morpholino triazine quaternary ammonium salts (bis‐mTQAS) is reported, starting from 2,4,6‐trichloro‐1,3,5‐triazine or 2,4‐dichloro‐6‐methoxy‐1,3,5‐triazine and various N‐alkylmorpholines. Bis‐mTQAS were tested as antimicrobials against Gram‐negative and Gram‐positive bacterial strains. The best‐performing bis‐mTQAS were found to achieve total disinfection against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 at 50 and 400 μg/mL, respectively. Distinctively, bis‐mTQAS with the highest antimicrobial efficiency had lowest cytotoxicity.
Highlights
Efficient, environmentally and economically sustainable, and nontoxic antibacterial products are of global relevance in the fight against microorganism contamination
Few features have been taken into consideration to achieve the proposed objective: 4 and other triazine derived quaternary ammonium salts prepared according to the literature are very efficient and reactive dehydro-condensation agents with reduced stability in solution.[14]
Since antimicrobial agents require to be stable in solution for long times, the stability of the triazine quaternary ammonium salts had to be improved
Summary
Environmentally and economically sustainable, and nontoxic antibacterial products are of global relevance in the fight against microorganism contamination. Few features have been taken into consideration to achieve the proposed objective: 4 and other triazine derived quaternary ammonium salts prepared according to the literature are very efficient and reactive dehydro-condensation agents with reduced stability in solution.[14] It is generally accepted that the presence of a methyl substituent on the tertiary amine
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