Abstract
Considering the promising antimicrobial activity of compounds bearing the thiazole or the oxadiazole rings in their structures, we set out to obtain new antimicrobial molecules bearing the 2-(thiazol-5-yl)-1,3,4-oxadiazole schaffold. The structures of the 8 new compounds obtained was confirmed by physicochemical characterization including: 1H-NMR, MS and elemental analysis. Antimicrobial activity was investigated against 5 Gram-positive bacterial strains, 2 Gram-negative bacterial strains and 2 fungal strains. The newly synthesized compounds showed modest antimicrobial activity.
Highlights
Considering the promising antimicrobial activity of compounds bearing the thiazole or the oxadiazole rings in their structures, we set out to obtain new antimicrobial molecules bearing the 2-(thiazol-5-yl)-1,3,4oxadiazole schaffold
A great deal of interested is still bestowed upon this molecular moiety by current research [4] that aims at identifying new lead compounds to act as: antineoplastic agents [5,6,7,8,9], prostaglandin receptor antagonists [10], antiprotozoal drugs [11,12] or antimicrobial agents [13]
Given our research group’s previous expertise concerning thiazole based antimicrobial agents [16,17,18,19,20,21,22,23,24], we decided to synthesize a new series of thiazolyl-1,3,4-oxadiazole derivatives in order to reunite the potential antimicrobial benefit of the 2 nuclei into a new scaffolds
Summary
Considering the promising antimicrobial activity of compounds bearing the thiazole or the oxadiazole rings in their structures, we set out to obtain new antimicrobial molecules bearing the 2-(thiazol-5-yl)-1,3,4oxadiazole schaffold. Oxadiazole is a versatile moiety present in a series of antimicrobial agents [14,15]. As such we set out to obtain new compounds that have a common motif of 2-(4-methyl-2- The resulting solid was filtered and washed with water in order to yield the pure compound [25,26].
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