Synthesis and Antimicrobial Activity of Some of Isoindolin-1-One-3-Phosphonates under Mild and Solvent-Free Conditions

Abstract

A range of N-substituted isoindolin-1-one-3-phosphonate compounds 4 under mild and solvent-free conditions was prepared. The synthesized compounds were screened for their antimicrobial activities against gram-positive bacterial strains (Micrococcus luteus, Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus), a gram-negative bacterial strain (Salmonella typhimurium). The compounds 4a and 4 b were the most active against M. luteus bacteria with inhibition zones (IZ) of 35 and 24 mm, respectively, and 4a was the most active against L. monocytogenes ATCC 1911 with an IZ of 22 mm. Minimum inhibitory concentration (MIC) of the synthesized compounds 4 and the two standards tetracycline and fluconazole was assessed against the four indicator microorganisms: L. monocytogenes ATCC 1911, S. aureus ATCC 6538, S. typhimurium ATCC 14028 and C. albicans (ATCC 90028). The lowest MIC values were obtained for the compound 4d. Against C. albicans (ATCC 90028).