Abstract
Six new chalcones were synthesised by condensing 2‐acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen‐Schmidt condensation. All these compounds were characterised by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.
Highlights
Chalcones either natural or synthetic are known to exhibit various biological activities
The presence of a reactive α,β-unsaturated keto function in chalcones is found to be responsible for their antimicrobial activity, which may be altered depending on the type and position of substituent on the aromatic rings
In the present communication we report the reaction of 2-acetyl pyridine with different aromatic aldehydes to form chalcones (1-6)
Summary
Chalcones either natural or synthetic are known to exhibit various biological activities. In the present communication we report the reaction of 2-acetyl pyridine with different aromatic aldehydes to form chalcones (1-6). The structures of the various synthesized compounds were assigned on the basis of elemental analyses, IR and 1H NMR spectral data. These compounds were screened for their antimicrobial activity.
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