Abstract
Synthesis of novel 5-methyl-1-(4-(6-methylimidazo[1,2- b ]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones (6) has been achieved by the reaction of 3-amino-5-methylisoxazole 1 with p -nitro phenacyl bromide, followed by reduction of 3 with stannous chloride. Compounds 4 on treatment with different aryl isothiocyanates in refluxing benzene, followed by trimolecular condensation with 30% HCHO and methyl amine in ethanol afforded the title compounds (6). The newly synthesized compounds ( 6) have been evaluated for their in vitro antimicrobial activity. Compounds 6 exhibited potent antimicrobial activity compared to that of standard drugs.
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