Abstract
AbstractNovel 3 substituted 1,5‐dihydro‐2,4,3‐benzodioxaphosphepine 3‐oxides (5a–h) were synthesized by reacting 1,2‐benzenedimethanol (1) with phosphorus tribromide in the presence of triethylamine at 0–30°C and subsequent reaction of the monobromide (2) with different Grignard reagents (3) at room temperature. The products (4) were converted to corresponding oxides 5a–i by oxidation with H2O2 at room temperature. The chemical structures of all the products were confirmed by analytical, IR and NMR (1H, 13C, and 31P) spectral data. Their antifungal and antibacterial activity is also evaluated. Most of these compounds exhibited moderate antimicrobial activity in the assay. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:572–575, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20154
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