Synthesis and antimicrobial activity of new adamantane derivatives III

Abstract

Some novel ester imides synthesised from trimellitic acid anhydride and 1-adamantanol or 2-adamantanol, were tested as antimicrobial compounds. Unfortunately, these agents showed a modest antibacterial activity (MIC>6 μg/ml). However, a comparison of these N-substituted adamantylester imides with the series published previously, indicated that the incorporation of l-alanine and l-phenylalanine into the phthalimide moiety was the best choice regardless of the series and leads to antimicrobial activity against Staphylococcus aureus strains.