Synthesis and Antimicrobial Activities of a Series of Disubstitutedarylazo-Barbituric- and Thiobarbituric Acid Derivatives

Abstract

A simple, convenient and reproducible synthesis of several new disubstitutedarylazo-barbituric and thiobarbituric acids is described. The method involves condensation with urea and thiourea of 2,4-disubstituted phenylhydrazones formed from the reactions of the parent aniline diazonium salts with diethylmalonate. These new compounds were preliminary evaluated for their antimicrobial activities against five bacterial strains covering both (Gram positive and Gram negative bacterial strains) and two fungi. Three of the newly-synthesized compounds showed promising antimicrobial activities with no signs of human cells cytotoxicity.