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Abstract
Abstract This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine.
Highlights
Malaria, a disease originating from Plasmodium, has been the enemy of mankind since hundreds of years back, and remains as a dangerous threat to public health in many tropical countries, including Indonesia
This work is licensed under the Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds 257 (Holeček et al, 1983; Khoo and Smith, 1981; Molloy et al, 1988; Sandhu et al, 1987; Swisher et al, 1984; Tzimopoulos et al, 2009) that need to be tested for their potential as antimalarial agents
The FT-IR spectrum of compound 1 is characterized by a strong band at wave number of 726.36 cm-1 indicating the presence of a Sn–O bond
Summary
A disease originating from Plasmodium, has been the enemy of mankind since hundreds of years back, and remains as a dangerous threat to public health in many tropical countries, including Indonesia. The recent results from the study on organotin(IV) compounds have demonstrated that several organotin(IV) carboxylates exhibit promising activities as biological agents. These compounds have been found to exhibit strong activity as antimalarial and antiplasmodial agents (Hadi et al, 2018b, 2019; Hansch and Verma 2009).
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