Abstract
Abstract The synthesis of several new anti-HIV-1 compounds is described. The new compounds contain a C2 symmetry axis and a dihidroxyethylene moiety based on the d -tartaric acid back bone. The synthesis of these compounds was achieved in 36–69% overall yields from d -tartaric acid. The protocol included: acetylation of hydroxyl groups, followed by diamide formation and deacetylation or reduction with LiAlH4. The anti-HIV 1 activities of these substances were evaluated in PM-1 cells, using Indinavir® as standard (IC50=0.2 μM). Two amino alcohol derivatives showed good inhibitory activity against the virus, with IC50=2.0 and 4 μM.
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